The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.
Identifieur interne : 000030 ( Main/Exploration ); précédent : 000029; suivant : 000031The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.
Auteurs : Yong-Yue Xu [République populaire de Chine] ; Dong-Mei Wang [République populaire de Chine] ; Hua-Sheng Liang [République populaire de Chine] ; Ze-Hao Liu [République populaire de Chine] ; Jun-Xia Li [République populaire de Chine] ; Mao-Jie Wang [République populaire de Chine, Pays-Bas] ; Xiu-Min Chen [République populaire de Chine] ; Deepak M W. Balak [Pays-Bas] ; Timothy R D J. Radstake [Pays-Bas] ; Run-Yue Huang [République populaire de Chine] ; Chuan-Jian Lu [République populaire de Chine]Source :
- The American journal of Chinese medicine [ 1793-6853 ] ; 2020.
Descripteurs français
- KwdFr :
- Angelica sinensis (MeSH), Astragalus (MeSH), Cellules Th17 (immunologie), Glycyrrhiza uralensis (MeSH), Humains (MeSH), Inflammation (immunologie), Inflammation (métabolisme), Inflammation (traitement médicamenteux), Lymphocytes T régulateurs (immunologie), Maladies du système immunitaire (immunologie), Maladies du système immunitaire (métabolisme), Maladies du système immunitaire (traitement médicamenteux), Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme), Médecine traditionnelle chinoise (MeSH), Médicaments issus de plantes chinoises (composition chimique), Médicaments issus de plantes chinoises (usage thérapeutique), Paeonia (MeSH), Phytothérapie (MeSH), Récepteur de type I du facteur de croissance transformant bêta (métabolisme), Récepteur de type II du facteur de croissance transformant bêta (métabolisme), Salvia (MeSH).
- MESH :
- composition chimique : Médicaments issus de plantes chinoises.
- immunologie : Cellules Th17, Inflammation, Lymphocytes T régulateurs, Maladies du système immunitaire.
- métabolisme : Inflammation, Maladies du système immunitaire, Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires, Récepteur de type I du facteur de croissance transformant bêta, Récepteur de type II du facteur de croissance transformant bêta.
- traitement médicamenteux : Inflammation, Maladies du système immunitaire.
- usage thérapeutique : Médicaments issus de plantes chinoises.
- Angelica sinensis, Astragalus, Glycyrrhiza uralensis, Humains, Médecine traditionnelle chinoise, Paeonia, Phytothérapie, Salvia.
English descriptors
- KwdEn :
- Angelica sinensis (MeSH), Astragalus Plant (MeSH), Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (therapeutic use), Glycyrrhiza uralensis (MeSH), Humans (MeSH), Immune System Diseases (drug therapy), Immune System Diseases (immunology), Immune System Diseases (metabolism), Inflammation (drug therapy), Inflammation (immunology), Inflammation (metabolism), Medicine, Chinese Traditional (MeSH), Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism), Paeonia (MeSH), Phytotherapy (MeSH), Receptor, Transforming Growth Factor-beta Type I (metabolism), Receptor, Transforming Growth Factor-beta Type II (metabolism), Salvia (MeSH), T-Lymphocytes, Regulatory (immunology), Th17 Cells (immunology).
- MESH :
- chemical , chemistry : Drugs, Chinese Herbal.
- chemical , metabolism : Nuclear Receptor Subfamily 1, Group F, Member 3, Receptor, Transforming Growth Factor-beta Type I, Receptor, Transforming Growth Factor-beta Type II.
- chemical , therapeutic use : Drugs, Chinese Herbal.
- drug therapy : Immune System Diseases, Inflammation.
- immunology : Immune System Diseases, Inflammation, T-Lymphocytes, Regulatory, Th17 Cells.
- metabolism : Immune System Diseases, Inflammation.
- Angelica sinensis, Astragalus Plant, Glycyrrhiza uralensis, Humans, Medicine, Chinese Traditional, Paeonia, Phytotherapy, Salvia.
Abstract
The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herbs from clinical trial data were performed. The studies reported the changes in the ratio of Th17 and/or Treg cells as well as their transcription factor and related cytokines were included. Frequency analysis of composition of the 39 assessed TCM prescriptions showed that Astragalus membranaceus var.mongholicus (5.20%), Glycyrrhiza uralensis (3.67%), Paeonia obovate (3.06%), Salvia digitaloides (3.06%), and Angelica sinensis (2.75%) were the top five herbal components, which were closely associated to the treatment of IMID. Network pharmacology showed that six target proteins (transforming growth factor (TGF)-beta receptor type-1, TGF-beta receptor type-2, retineic-acid-receptor-related orphan nuclear receptor gamma (ROR-gamma), TGFB2, IL-17 and IL-2, respectively) might be involved in the regulatory effects of TCM on Th17/Treg axis. Moreover, there were nine active ingredients (including Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin and Chlorogenic acid) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis. The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies. Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.
DOI: 10.1142/S0192415X20500275
PubMed: 32345031
Affiliations:
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R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Dong Mei" sort="Wang, Dong Mei" uniqKey="Wang D" first="Dong-Mei" last="Wang">Dong-Mei Wang</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liang, Hua Sheng" sort="Liang, Hua Sheng" uniqKey="Liang H" first="Hua-Sheng" last="Liang">Hua-Sheng Liang</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Ze Hao" sort="Liu, Ze Hao" uniqKey="Liu Z" first="Ze-Hao" last="Liu">Ze-Hao Liu</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Jun Xia" sort="Li, Jun Xia" uniqKey="Li J" first="Jun-Xia" last="Li">Jun-Xia Li</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Mao Jie" sort="Wang, Mao Jie" uniqKey="Wang M" first="Mao-Jie" last="Wang">Mao-Jie Wang</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Chen, Xiu Min" sort="Chen, Xiu Min" uniqKey="Chen X" first="Xiu-Min" last="Chen">Xiu-Min Chen</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Balak, Deepak M W" sort="Balak, Deepak M W" uniqKey="Balak D" first="Deepak M W" last="Balak">Deepak M W. Balak</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Radstake, Timothy R D J" sort="Radstake, Timothy R D J" uniqKey="Radstake T" first="Timothy R D J" last="Radstake">Timothy R D J. Radstake</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Huang, Run Yue" sort="Huang, Run Yue" uniqKey="Huang R" first="Run-Yue" last="Huang">Run-Yue Huang</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lu, Chuan Jian" sort="Lu, Chuan Jian" uniqKey="Lu C" first="Chuan-Jian" last="Lu">Chuan-Jian Lu</name><affiliation wicri:level="1"><nlm:affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">The American journal of Chinese medicine</title><idno type="eISSN">1793-6853</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angelica sinensis (MeSH)</term><term>Astragalus Plant (MeSH)</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (therapeutic use)</term><term>Glycyrrhiza uralensis (MeSH)</term><term>Humans (MeSH)</term><term>Immune System Diseases (drug therapy)</term><term>Immune System Diseases (immunology)</term><term>Immune System Diseases (metabolism)</term><term>Inflammation (drug therapy)</term><term>Inflammation (immunology)</term><term>Inflammation (metabolism)</term><term>Medicine, Chinese Traditional (MeSH)</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism)</term><term>Paeonia (MeSH)</term><term>Phytotherapy (MeSH)</term><term>Receptor, Transforming Growth Factor-beta Type I (metabolism)</term><term>Receptor, Transforming Growth Factor-beta Type II (metabolism)</term><term>Salvia (MeSH)</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>Th17 Cells (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Angelica sinensis (MeSH)</term><term>Astragalus (MeSH)</term><term>Cellules Th17 (immunologie)</term><term>Glycyrrhiza uralensis (MeSH)</term><term>Humains (MeSH)</term><term>Inflammation (immunologie)</term><term>Inflammation (métabolisme)</term><term>Inflammation (traitement médicamenteux)</term><term>Lymphocytes T régulateurs (immunologie)</term><term>Maladies du système immunitaire (immunologie)</term><term>Maladies du système immunitaire (métabolisme)</term><term>Maladies du système immunitaire (traitement médicamenteux)</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme)</term><term>Médecine traditionnelle chinoise (MeSH)</term><term>Médicaments issus de plantes chinoises (composition chimique)</term><term>Médicaments issus de plantes chinoises (usage thérapeutique)</term><term>Paeonia (MeSH)</term><term>Phytothérapie (MeSH)</term><term>Récepteur de type I du facteur de croissance transformant bêta (métabolisme)</term><term>Récepteur de type II du facteur de croissance transformant bêta (métabolisme)</term><term>Salvia (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nuclear Receptor Subfamily 1, Group F, Member 3</term><term>Receptor, Transforming Growth Factor-beta Type I</term><term>Receptor, Transforming Growth Factor-beta Type II</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Immune System Diseases</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules Th17</term><term>Inflammation</term><term>Lymphocytes T régulateurs</term><term>Maladies du système immunitaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immune System Diseases</term><term>Inflammation</term><term>T-Lymphocytes, Regulatory</term><term>Th17 Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Immune System Diseases</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Inflammation</term><term>Maladies du système immunitaire</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires</term><term>Récepteur de type I du facteur de croissance transformant bêta</term><term>Récepteur de type II du facteur de croissance transformant bêta</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Inflammation</term><term>Maladies du système immunitaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Angelica sinensis</term><term>Astragalus Plant</term><term>Glycyrrhiza uralensis</term><term>Humans</term><term>Medicine, Chinese Traditional</term><term>Paeonia</term><term>Phytotherapy</term><term>Salvia</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Angelica sinensis</term><term>Astragalus</term><term>Glycyrrhiza uralensis</term><term>Humains</term><term>Médecine traditionnelle chinoise</term><term>Paeonia</term><term>Phytothérapie</term><term>Salvia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herbs from clinical trial data were performed. The studies reported the changes in the ratio of Th17 and/or Treg cells as well as their transcription factor and related cytokines were included. Frequency analysis of composition of the 39 assessed TCM prescriptions showed that <i>Astragalus membranaceus var.mongholicus</i> (5.20%), <i>Glycyrrhiza uralensis</i> (3.67%), <i>Paeonia obovate</i> (3.06%), <i>Salvia digitaloides</i> (3.06%), and <i>Angelica sinensis</i> (2.75%) were the top five herbal components, which were closely associated to the treatment of IMID. Network pharmacology showed that six target proteins (transforming growth factor (TGF)-beta receptor type-1, TGF-beta receptor type-2, retineic-acid-receptor-related orphan nuclear receptor gamma (ROR-gamma), TGFB2, IL-17 and IL-2, respectively) might be involved in the regulatory effects of TCM on Th17/Treg axis. Moreover, there were nine active ingredients (including <i>Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin</i> and <i>Chlorogenic acid</i>) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis. The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies. Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32345031</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1793-6853</ISSN><JournalIssue CitedMedium="Internet"><Volume>48</Volume><Issue>3</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>The American journal of Chinese medicine</Title><ISOAbbreviation>Am J Chin Med</ISOAbbreviation></Journal><ArticleTitle>The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.</ArticleTitle><Pagination><MedlinePgn>535-558</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1142/S0192415X20500275</ELocationID><Abstract><AbstractText>The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herbs from clinical trial data were performed. The studies reported the changes in the ratio of Th17 and/or Treg cells as well as their transcription factor and related cytokines were included. Frequency analysis of composition of the 39 assessed TCM prescriptions showed that <i>Astragalus membranaceus var.mongholicus</i> (5.20%), <i>Glycyrrhiza uralensis</i> (3.67%), <i>Paeonia obovate</i> (3.06%), <i>Salvia digitaloides</i> (3.06%), and <i>Angelica sinensis</i> (2.75%) were the top five herbal components, which were closely associated to the treatment of IMID. Network pharmacology showed that six target proteins (transforming growth factor (TGF)-beta receptor type-1, TGF-beta receptor type-2, retineic-acid-receptor-related orphan nuclear receptor gamma (ROR-gamma), TGFB2, IL-17 and IL-2, respectively) might be involved in the regulatory effects of TCM on Th17/Treg axis. Moreover, there were nine active ingredients (including <i>Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin</i> and <i>Chlorogenic acid</i>) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis. The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies. Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yong-Yue</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dong-Mei</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Hua-Sheng</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ze-Hao</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jun-Xia</ForeName><Initials>JX</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Mao-Jie</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiu-Min</ForeName><Initials>XM</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balak</LastName><ForeName>Deepak M W</ForeName><Initials>DMW</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radstake</LastName><ForeName>Timothy R D J</ForeName><Initials>TRDJ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Run-Yue</ForeName><Initials>RY</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Chuan-Jian</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>The Second Clinical College, Guangzhou University of Chinese Medicine, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, P. R. China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese, Medicine Syndrome, Guangzhou 510120, P. R. China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D000078182">Systematic Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Singapore</Country><MedlineTA>Am J Chin Med</MedlineTA><NlmUniqueID>7901431</NlmUniqueID><ISSNLinking>0192-415X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057132">Nuclear Receptor Subfamily 1, Group F, Member 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.30</RegistryNumber><NameOfSubstance UI="D000077293">Receptor, Transforming Growth Factor-beta Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.30</RegistryNumber><NameOfSubstance UI="D000077294">Receptor, Transforming Growth Factor-beta Type II</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.30</RegistryNumber><NameOfSubstance UI="C000625845">TGFBR2 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D029971" MajorTopicYN="N">Angelica sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027883" MajorTopicYN="N">Astragalus Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029882" MajorTopicYN="N">Glycyrrhiza uralensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007154" MajorTopicYN="N">Immune System Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008516" MajorTopicYN="Y">Medicine, Chinese Traditional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057132" MajorTopicYN="N">Nuclear Receptor Subfamily 1, Group F, Member 3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029596" MajorTopicYN="N">Paeonia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="Y">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077293" MajorTopicYN="N">Receptor, Transforming Growth Factor-beta Type I</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000077294" MajorTopicYN="N">Receptor, Transforming Growth Factor-beta Type II</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027544" MajorTopicYN="N">Salvia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058504" MajorTopicYN="N">Th17 Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Immune-Mediated Inflammatory Diseases</Keyword><Keyword MajorTopicYN="N">Systematic Review</Keyword><Keyword MajorTopicYN="N">Th17/Treg Cells</Keyword><Keyword MajorTopicYN="N">Traditional Chinese Medicine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32345031</ArticleId><ArticleId IdType="doi">10.1142/S0192415X20500275</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li><li>République populaire de Chine</li></country><region><li>Guangdong</li><li>Utrecht (province)</li></region><settlement><li>Jiangmen</li><li>Utrecht</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Xu, Yong Yue" sort="Xu, Yong Yue" uniqKey="Xu Y" first="Yong-Yue" last="Xu">Yong-Yue Xu</name></region><name sortKey="Chen, Xiu Min" sort="Chen, Xiu Min" uniqKey="Chen X" first="Xiu-Min" last="Chen">Xiu-Min Chen</name><name sortKey="Huang, Run Yue" sort="Huang, Run Yue" uniqKey="Huang R" first="Run-Yue" last="Huang">Run-Yue Huang</name><name sortKey="Huang, Run Yue" sort="Huang, Run Yue" uniqKey="Huang R" first="Run-Yue" last="Huang">Run-Yue Huang</name><name sortKey="Li, Jun Xia" sort="Li, Jun Xia" uniqKey="Li J" first="Jun-Xia" last="Li">Jun-Xia Li</name><name sortKey="Liang, Hua Sheng" sort="Liang, Hua Sheng" uniqKey="Liang H" first="Hua-Sheng" last="Liang">Hua-Sheng Liang</name><name sortKey="Liu, Ze Hao" sort="Liu, Ze Hao" uniqKey="Liu Z" first="Ze-Hao" last="Liu">Ze-Hao Liu</name><name sortKey="Lu, Chuan Jian" sort="Lu, Chuan Jian" uniqKey="Lu C" first="Chuan-Jian" last="Lu">Chuan-Jian Lu</name><name sortKey="Lu, Chuan Jian" sort="Lu, Chuan Jian" uniqKey="Lu C" first="Chuan-Jian" last="Lu">Chuan-Jian Lu</name><name sortKey="Wang, Dong Mei" sort="Wang, Dong Mei" uniqKey="Wang D" first="Dong-Mei" last="Wang">Dong-Mei Wang</name><name sortKey="Wang, Mao Jie" sort="Wang, Mao Jie" uniqKey="Wang M" first="Mao-Jie" last="Wang">Mao-Jie Wang</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Wang, Mao Jie" sort="Wang, Mao Jie" uniqKey="Wang M" first="Mao-Jie" last="Wang">Mao-Jie Wang</name></region><name sortKey="Balak, Deepak M W" sort="Balak, Deepak M W" uniqKey="Balak D" first="Deepak M W" last="Balak">Deepak M W. Balak</name><name sortKey="Radstake, Timothy R D J" sort="Radstake, Timothy R D J" uniqKey="Radstake T" first="Timothy R D J" last="Radstake">Timothy R D J. Radstake</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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